I wish to set up a server-side autoresponder for a distribution list but cannot do it from the Mail Flow. I would like to set up distribution and send automated responses to emails received. Is this possible right now in Exchange Online?
Hi @Hughes, Welcome to the community 
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First of all, A distribution group doesn’t actually handle emails it simply passes a copy of the members within it, so you cant use auto-replies on it directly.
It is a disappointment that we do not have a straightforward way to achieve this. Therefore you have to create a mailbox account, make it a member of the Distribution Group and configure reply rule on that mailbox.
Also for this to work you have to enable “Send out-of-office message to originator” on the Distribution Group properties.
Hope this helps let me know if you have any questions
